Molecular Entomology and Genome Editing

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• Alon DM, Mittelman K, Stibbe E, Countryman S, Stodieck L, Doraisingam S, Martin DML, Hamo ER, Pines G§, Burstein D§, CRISPR-based genetic diagnostics in microgravity, Biosensors and Bioelectronics, 2023, https://doi.org/10.1016/j.bios.2023.115479 Link

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• Dan Mark Alon,Tamir Partosh,David Burstein,Gur Pines, Rapid and sensitive on-site genetic diagnostics of pest fruit flies using CRISPR-Cas12a, Pest Management Science, Link

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• Gur Pines, Assaf Pines, Carrie A Eckert, Highly efficient libraries design for saturation mutagenesis, Synthetic Biology 2022, Volume 7, Issue 1, 2022, ysac006, Link

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• Beatrice T. Nganso, Gur Pines, and Victoria Soroker, Insights into gene manipulation techniques for Acari functional genomics. Insect Biochemistry and Molecular Biology, 143 (2022) 103705, DOI: https://doi.org/10.1016/j.ibmb.2021.103705  Link

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• ​Dan Mark Alon, Hagit Hak, Menachem Bornstein, Gur Pines,* and Ziv Spiegelman*., Differential Detection of the Tobamoviruses Tomato MosaicVirus (ToMV) and Tomato Brown Rugose Fruit Virus (ToBRFV)Using CRISPR-Cas12a. Plants 2021, 10(6), 1256; https://doi.org/10.3390/plants10061256 Link

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• Gur Pines, Reilly G. Fankhauser and Carrie A. Eckert, Predicting Drug Resistance Using DeepMutational Scanning. Molecules 2020,25, 2265; doi:10.3390/molecules25092265 Link

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• Pines G, Oh EJ, Bassalo MC, Choudhury A, Garst AD, Fankhauser RG, Eckert CA, Gill RT., Isolation of Genomic Deoxyxylulose Phosphate Reductoisomerase (DXR) Mutations Conferring Resistance to Fosmidomycin. ACS Synthetic Biology, DOI: 10.1021/acssynbio.8b00219 Link

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• Pines G and Gill RT, Dynamic Management of Codon Compression for Saturation Mutagenesis. Methods Mol Biol. Springer 2018; 1772:171-189. (Book chapter) Link

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• Freed EF, Pines G, Eckert CA, Gill RT, Trackable multiplex recombineering (TRMR) and next-generation genome design technologies. Synthetic Biology: Parts, Devices and Applications, Wiley 2018, 8, 215. (Book chapter) Link

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• Roth L, Lindzen M, Sas-Chen A, Noronha A, Sheffer M, Mancini M, Enuka Y, Tarcic G, Pines G, Lauriola M, Nevo N, Porat Z, Sevilla-Sharon M, Carvalho S, Ziv T, Gueda O, Domany E, Admon A, Caldas C and Yarden Y, Phosphoproteomics identify ladinin-1, a marker of poor breast cancer prognosis, as a cytoskeletal effector of EGFR, Science  Signaling 2018 Jan 30;11(515) Link

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• Pines G*, Winkler JD*, Assaf Pines, Gill RT., Refactoring the Genetic Code for Increased Evolvability. mBio, 2017 Nov 14;8(6). pii:e01654-17 Link

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• Zeitoun RI, Pines G, Grau WC, Gill RT, Quantitative tracking of combinatorially engineered populations with multiplexed binary assemblies. ACS Synthetic Biology, 2017 Apr 21;6(4):619-627 Link

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• Garst AD, Bassalo MC, Pines G, Lynch SA, Halweg-Edwards AL, Liu R, Wang ZW, Zeitoun RI, Gill RT., Genome-wide mapping of mutations at single-nucleotide resolution for protein, metabolic and genome engineering, Nature Biotechnology, 2017 Jan;35(1):48-55. Link

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• Winkler JD, Halweg-Edwards AL, Erickson KE, Choudhury A, Pines G, Gill RT., The Resistome: A Comprehensive Database of Escherichia coli Resistance Phenotypes., ACS Synthetic Biology, 2016 Dec 16;5(12):1566-1577. Link

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• Bublil E, Cohen T, Arnusch C, Peleg A, Pines G, Lavi S, Yarden Y, Shai Y., Interfering with the Dimerization of the ErbB Receptors by Transmembrane Domain Derived Peptides Inhibits Tumorigenic Growth in Vitro and In Vivo, Biochemistry, 2016 Oct 4;55(39):5520-5530. Link

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• Halweg-Edwards AL*, Pines G*, Winkler JD, Pines A, Gill RT., A Web Interface for Codon Compression., ACS Synthetic Biology, 2016 Sep 16;5(9):1021-3. Link

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• Itan Y, Gerbault P, Pines G., Evolutionary Genomics., Evolutionary Bioinformatics, 2016 Apr 20;11(Suppl 2):53-5 (Editorial) Link

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• Pines G, Freed EF, Winkler JD, Gill RT., Bacterial recombineering - genome engineering via phage-based homologous recombination., ACS Synthetic Biology, 2015 Nov 20;4(11):1176-85. (Review) Link

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• Zeitoun RI, Garst AD, Degen GD, Pines G, Mansell TJ, Glebes TY, Boyle NR, Gill RT., Multiplexed tracking of combinatorial genomic mutations in engineered cell populations., Nature Biotechnology, 2015 Jun;33(6):631-7. Link

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• Pareja F, Pines G and Yarden, Y, Receptor Tyrosine Kinases: Family and Subfamilies. 107-164: EGFR/ERBB Receptor Tyrosine Kinase Family. Springer International Publishing, 2015. (Book chapter) Link

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• Pines G, Pines A, Garst AD, Zeitoun RI, Lynch S and Gill RT., Codon Compression Algorithms for Saturation Mutagenesis., ACS Synthetic Biology, 2015 May 15;4(5):604-14. Link

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• Pareja F, Ferraro DA, Rubin C, Cohen-Dvashi H, Zhang F, Aulmann S, Ben-Chetrit N, Pines G, Navon R, Crosetto N, Köstler W, Carvalho S, Lavi S, Schmitt F, Dikic I, Yakhini Z, Sinn P, Mills GB, Yarden Y., Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression., Oncogene, 2012 Oct 25;31(43):4599-608. Link

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• Yarden Y, Pines G., The ERBB Network: At last, cancer therapy meets systems biology., Nature Reviews Cancer, 2012 Jul 12;12(8):553-63. (Review) Link

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• Tarcic G, Avraham R, Pines G, Amit I, Shay T, Lu Y, Zwang Y, Katz M, Ben-Chetrit N, Jacob-Hirsch J, Virgilio L, Rechavi G, Mavrothalassitis G, Mills GB, Domany E, Yarden Y., EGR1 and the ERK-ERF axis drive mammary cell migration in response to EGF., The FASEB Journal, 2012 Apr;26(4):1582-92 Link

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• Bublil EM, Pines G, Patel G, Fruhwirth G, Ng T, Yarden Y., Kinase-mediated quasi-dimers of EGFR., The FASEB Journal, 2010 Dec;24(12):4744-55. Link

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• Pines G, Huang PH, Zwang Y, White FM, Yarden Y., EGFRvIV: A previously uncharacterized oncogenic mutant reveals a kinase autoinhibitory mechanism., Oncogene, 2010 Oct 28;29(43):5850-60. Link

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• Pines G, Köstler WJ, Yarden Y., Oncogenic mutant forms of EGFR: Lessons in signal transduction and targets for cancer therapy., FEBS Letters, 2010 Jun 18;584(12):2699-706. (Review) Link

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• Shtiegman K, Kochupurakkal BS, Zwang Y, Pines G, Starr A, Vexler A, Citri A, Katz M, Lavi S, Ben-Basat Y, Benjamin S, Corso S, Gan J, Yosef RB, Giordano S, Yarden Y., Defective ubiquitinylation of EGFR mutants of lung cancer confers prolonged signaling., Oncogene, 2007 Oct 25;26(49):6968-78. Link